Driving Directions South Guelph

South Guelph, Ontario, is a charming and growing community located just minutes from the heart of downtown Guelph. Nestled in southwestern Ontario, South Guelph is highly accessible from several major cities, making it a convenient destination for commuters, day-trippers, and new residents alike. Whether you’re coming from Toronto, Kitchener-Waterloo, Hamilton, or Mississauga, reaching South Guelph by car is straightforward and scenic.

From Toronto (Approx. 1 hour, 15 minutes):

Take Highway 401 West toward London. After about 70 kilometers, take exit 295 for Highway 6 North toward Guelph. Continue north on Hwy 6 (also called Hanlon Parkway once you’re in Guelph) for approximately 10–15 minutes. Exit at Kortright Road, Clair Road, or College Avenue for access to various parts of South Guelph. This route is a direct and efficient way into the southern part of the city, with smooth highway driving for most of the journey.

From Kitchener-Waterloo (Approx. 30–40 minutes):

Head east via Highway 7 toward Guelph. Once you enter the city, follow signage for the Hanlon Expressway (Hwy 6 South), which runs north–south through Guelph. Take the appropriate exit (Kortright, Stone Road, or Clair Road) to reach your destination in South Guelph. This is a short, well-maintained route that offers easy access for commuters and students heading to the University of Guelph or nearby business parks.

From Hamilton (Approx. 50 minutes):

Drive north on Highway 6 from Hamilton. Once you pass through rural areas and smaller communities, continue following signs for Guelph. You’ll eventually merge onto the Hanlon Parkway, which leads directly into South Guelph. Exit at key roads like Arkell, Clair, or College Avenue for access to residential areas, shopping centres, and schools.

From Mississauga or Oakville (Approx. 50–60 minutes):

Start by taking the QEW or Highway 403 westbound until you reach Highway 6 North. Follow Hwy 6 all the way to the Hanlon Expressway in Guelph, then continue north until you hit your preferred South Guelph exit. The drive is direct and provides access to green spaces and suburban neighbourhoods along the way.

No matter where you’re coming from, South Guelph is an easy drive thanks to its proximity to Highway 401 and well-connected regional routes. With plenty of signage and accessible exits, arriving in South Guelph is as stress-free as living there.

Ready for your appointment? Return to the South Guelph Clinic Hub for services & booking.